Immunotherapy: A Cutting Edge Approach to Food Allergies
15 July 2021
Immunotherapy: A Cutting Edge Approach to Food Allergies

With traditional treatment for food allergies increasing in costs without improving quality of life, those suffering through food allergies are calling for a more innovative approach -- oral immunotherapy.

Food allergies are potentially life-threatening. Affecting up to 8% of children and 2-3% of adults in the United States, food allergies pose a major public health concern and continues to rise. Traditional treatments for food allergies center around strict allergen avoidance along with constant carrying of rescue medications such as epinephrine. However, there’s a new, cutting-edge treatment option becoming available to the masses -- Oral Immunotherapy.


Individuals with food allergies must often carry epinephrine on their person, read labels closely, and live in constant vigilance of what they come into contact with. For example, a common peanut allergy can cost up to
$6,400 a year in healthcare costs, severely diminishing the quality of life for those affected.


This highlights an urgent need for alternative options for those struggling with food allergies. And alternatives are coming about -- currently, peanut oral immunotherapy (OIT) is one of the most investigated alternative options.


What Is Oral Immunotherapy?

For every individual, there is a certain limit, or threshold, of the allergen they can consume. If too much is consumed, that threshold has been breached and an allergic response is triggered. Oral Immunotherapy (OIT) refers to the ingestion of the allergen in a slowly increasing amount to increase the threshold of reaction. For example, a person allergic to peanuts may be given minuscule amounts of peanut protein to introduce the allergen without triggering a response. 


This amount is gradually increased over a period of months and under the supervision of a licensed professional. Eventually, the threshold is increased, allowing the allergic individual protection against accidental ingestion of the allergen. 


How Immunotherapy Desensitizes Food Allergies

The concept of Immunotherapy revolves around the idea of creating a desensitized state in allergic individuals. This desensitization state relies on the ongoing exposure of the allergen -- with 60-80% of patient studies showing a desensitized state with ongoing therapy.


Some studies have looked into a desensitized state of sustained unresponsiveness -- that is the retention of protective benefits from OIT that is not reliant on ongoing exposure. The two most popular Immunotherapy treatments, peanut and milk, are reported to induce sustained unresponsiveness in approximately
30 to 70+% of individuals. However, this has not been adequately studied.


As of now, it is assumed that some degree of ongoing exposure will be required for the majority of individuals receiving oral immunotherapy.


A Cutting-Edge FDA-Approved Treatment Plan

Peanut oral immunotherapy is one of the most studied experimental therapies and recently launched an FDA-approved product, Palforzia. This product could be a promising option for peanut-allergic patients, as well as improving food allergy-related quality of life in certain individuals. This could mean a complete lifestyle game-changer for both children and adults!


Completing an oral immunotherapy program may help children participate in snack time at school without worrying about ending up in the emergency department or eat packaged foods with ambiguous labeling. Families can venture out to restaurants and adults may attend their friends’ backyard barbecues or grab a drink at a bar that also serves nuts.


However, peanut oral immunotherapy is not without the potential of side effects, including allergic reactions.


More answers to come 

When monitoring the effects of oral immunotherapy, the most common side effects involve the GI tract. However, it is not always clear these effects were directly caused by the therapy. Other commonly reported side effects of increasing the allergen dosage too soon include oral itching, rash, hives, and swelling.


As this type of immunotherapy becomes common, many questions will soon be answered.


For instance:

  • What will be the exact level of protection?
  • Will regular immunotherapy allow individuals to reliably eat precautionary products? 
  • Will we eventually get an exact and consistent length of treatment and dosage?. 
  • Will we be able to predict an individual’s response to treatment?
  • Will long-term treatment become sustainable?
  • Could OIT be combined with another therapy to improve safety and efficacy?


Treatment For Your Specific Food Allergy

While desensitization is successful in the majority of patients, much larger and longitudinal studies are needed in order to evaluate the clinical applicability of immunotherapy. These studies will include long-term effectiveness as well as the effect on the quality of life. 


Future research will also evaluate the short- and long-term effectiveness of the therapy, as well as provide predictors of important treatment outcomes. As of now, however, OIT is the leading investigational and marketed treatment for those seeking increased protection from food allergy reactions.


However, scientists know these treatments are not a one size fits all approach. Specific food allergies, health conditions, and more could determine the effectiveness of OIT for certain individuals. As other investigational therapies arise, they may carry different risks and benefits. Ultimately, the choice of treatment will be based on individual and family factors after careful discussion with one’s physician.


Allergy Affiliates Inc, located in Bradenton, Fla., is offering immunotherapy for food allergies. Contact us today to learn about your options.

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by Allergy Affiliates 20 July 2025
Understanding Insect Sting Allergies Introduction Insect sting allergies can range from minor irritations to severe, life-threatening reactions. As individuals enjoy outdoor activities, the risk of insect stings and the potential for an allergic reaction increases. Understanding the nature of these allergies and exploring the available treatment options can significantly enhance safety and quality of life for those who are allergic. This article delves into the symptoms, risk factors, and diagnostic approaches related to insect sting allergies, aiming to provide a comprehensive guide for managing and treating these conditions effectively. Understanding Insect Sting Allergies Insect stings can elicit allergic reactions when a person's immune system overreacts to the venom injected by insects such as bees, wasps, hornets, yellow jackets, or fire ants. For individuals with insect sting allergies, exposure can lead to intense reactions, making it crucial to recognize symptoms and take preventive measures. Common Symptoms and Reactions The symptoms of insect sting allergies can vary from mild to severe and may occur immediately after the sting or develop over a few hours. Common symptoms include: - Localized Reactions : Initial signs typically involve redness, swelling, and pain at the sting site. These symptoms are common and usually subside within a few hours. - Mild Systemic Reactions : These extend beyond the sting site, causing hives, itchiness, or swelling in other body parts. - Severe Systemic Reactions (Anaphylaxis) : In sensitized individuals, this can lead to difficulty breathing, a drop in blood pressure, nausea, vomiting, diarrhea, and even loss of consciousness. Anaphylaxis is a medical emergency requiring immediate attention and treatment with an epinephrine auto-injector. Understanding and recognizing these symptoms are vital, especially for individuals living in areas with high insect activity or those with a history of reactions. Risk Factors for Severe Allergic Reactions Certain factors may increase individuals' risk of developing severe allergic reactions to insect stings: - Previous Anaphylactic Reactions : Those who have experienced severe reactions in the past are more likely to have similar or worse reactions upon subsequent stings. - Multiple Stings : Receiving multiple stings at once can increase venom levels in the body, heightening the risk of a severe reaction. - Underlying Health Conditions : Conditions such as asthma or a family history of allergic reactions may predispose some individuals to more intense reactions. - Age and Occupation : Young children and adults who work outdoors or engage in activities where insects are common may face enhanced exposure risk. Reducing these risks involves proactive measures such as wearing protective clothing and utilizing insect repellents when necessary. Diagnosing Insect Sting Allergies Accurate diagnosis is critical for managing insect sting allergies effectively. Diagnostic processes typically include: - Detailed Medical History : A physician will review the patient’s reaction history, identifying possible insect sting triggers and assessing previous symptoms. - Skin Testing : This involves placing small amounts of insect venom on the skin's surface with a small needle prick. Observing the skin's reaction helps determine sensitization. - Blood Tests : Specific IgE blood tests can confirm the presence of antibodies to particular insect venoms, providing further insight into allergy severity. Seeking consultation with an allergist is essential for individuals who suspect an allergy. Such specialists can effectively evaluate symptoms and provide a tailored treatment plan that may include prescription of emergency medication and discussing long-term management strategies such as venom immunotherapy. Experts can effectively evaluate symptoms and provide a personalized treatment plan. This may involve prescribing emergency medication and exploring long-term management options such as venom immunotherapy. The ability to recognize and address insect sting allergies adequately can substantially reduce their impact on one's daily life and offer a sense of security during outdoor pursuits. It is essential for those with known allergies to consult an allergist regularly and remain educated on the latest developments in treatment and prevention strategies. Immediate Treatment Options When an insect sting occurs, it is crucial to act swiftly to manage symptoms and prevent severe reactions. Immediate treatment not only alleviates discomfort but also plays a critical role in averting life-threatening situations. Below, we explore basic first aid measures, emergency responses for severe reactions, and the strategic use of epinephrine auto-injectors. Basic First Aid for Insect Stings Basic first aid can be immensely helpful in reducing pain and swelling following an insect sting. Here are the essential steps: - Remove the Stinger : If a stinger is still lodged in the skin, carefully scrape it out with a blunt object like a credit card. Avoid using tweezers, as squeezing the stinger can release more venom. - Clean the Area : Wash the affected area with soap and water to remove dirt and prevent infection. - Apply a Cold Compress : Use an ice pack or a cloth soaked in cold water to reduce swelling and numb the pain. Apply it intermittently for 10-minute intervals. - Take Oral Antihistamines : Over-the-counter antihistamines, such as diphenhydramine (Benadryl), can help mitigate itching and swelling. - Apply Topical Treatments : Hydrocortisone cream or calamine lotion may be used to soothe itching and irritation. These steps are effective for mild reactions, but they are not sufficient for severe allergic responses. Emergency Response for Severe Reactions A serious allergic reaction, or anaphylaxis, to an insect sting requires immediate medical attention. Recognizing the symptoms is the first critical step. Symptoms may include trouble breathing, swelling of the face or throat, rapid pulse, dizziness, or loss of consciousness. If anaphylaxis is suspected: - Call 911 Immediately : Emergency medical personnel can provide life-saving interventions. - Position the Victim Properly : Lay the person flat and elevate their legs slightly. If they are vomiting or have trouble breathing, turn them on their side. - Monitor Breathing and Circulation : Be prepared to administer CPR if the person ceases to breathe or their heart stops. The Use of Epinephrine Auto-Injectors Epinephrine auto-injectors are essential tools for those with known severe insect sting allergies. Here’s how to use them effectively: - Know When to Use It : Administer the auto-injector at the first sign of a severe allergic reaction. - Follow the Instructions : Familiarize yourself with the specific auto-injector you have, as instructions can vary slightly. - Administer the Injection : Inject into the outer thigh, pressing firmly until the needle is deployed. Hold it in place as directed to ensure the medication is fully delivered. - Seek Emergency Medical Attention : Using an epinephrine auto-injector is only a part of the emergency response. Further medical evaluation and treatment are necessary even if symptoms temporarily subside. Long-Term Treatment Solutions Beyond immediate intervention, it is essential for individuals with severe insect allergies to pursue long-term treatment strategies. These treatments can significantly reduce the risk of future reactions and improve quality of life. Allergy Shots for Bee and Wasp Stings Allergy shots, officially known as allergen immunotherapy, are a common long-term treatment for insect sting allergies. They involve periodic injections of small amounts of venom to build up immunity over time. The procedure generally follows two phases: - Build-Up Phase : Injections are given weekly or bi-weekly for several months, gradually increasing in dosage. - Maintenance Phase : Once the optimum dosage is reached, injections are administered monthly for three to five years. Venom Immunotherapy Explained Venom immunotherapy (VIT) is highly effective in preventing future allergic reactions to insect stings. Here’s what you need to know: - Effectiveness : VIT can reduce the risk of systemic allergic reactions from stings by approximately 97% after adequate treatment. - Eligibility : Most individuals who have experienced an anaphylactic reaction to insect stings are candidates for VIT. - Commitment : VIT requires regular follow-up with an allergist, making adherence crucial for long-term success. Rush Immunotherapy for Quick Protection For those in need of rapid protection, rush immunotherapy offers an accelerated solution. - Process : Multiple injections are administered over a few days to quickly build up immunity. - Benefits : This approach provides faster protection, which can be beneficial for those entering an active insect season. - Considerations : While effective, rush immunotherapy may present a higher risk of side effects and requires close medical supervision. Exploring these long-term treatment solutions with a qualified allergist ensures that individuals with insect sting allergies find the most suitable strategy tailored to their needs and lifestyle. Through a combination of immediate and ongoing care, the risk and severity of allergic reactions can be greatly minimized. Preventive Measures for Insect Sting Allergies Preventive measures are crucial for individuals prone to insect sting allergies. By implementing effective strategies, it is possible to reduce the likelihood of stings and subsequent allergic reactions. Identifying and Avoiding High-Risk Areas Insects such as bees, wasps, hornets, and fire ants are known offenders when it comes to stings. These stinging insects are often found in specific environments: - Gardens and Parks : Flowering plants attract bees, while picnic areas often become breeding grounds for these insects. - Wooded Areas : Hornets and wasps typically construct their nests in trees. - Yards with Unattended Trash : Open garbage cans or uncovered food can draw these insects. To minimize exposure, it is advisable to familiarize yourself with these areas and adjust your outdoor activities accordingly. Tips for Reducing Exposure to Stinging Insects There are numerous effective practices that can help reduce exposure to stinging insects: - Dress Appropriately : Wearing long-sleeved shirts and pants can provide a barrier against stings. - Avoid Using Strong Fragrances : Perfumes and scented lotions can attract insects. - Choose Light-Colored Clothing : Dark or bright colors might attract more attention from bees and wasps. - Inspect Outdoor Areas : Before settling down for outdoor activities, ensure the area is clear of nests and active insects. - Secure Food and Drinks : Keep food covered and drinks sealed to avoid attracting stingers. By incorporating these tips into your daily routine, you can greatly lessen the risk of encountering stinging insects. Preventive Options for Children Children are particularly vulnerable to insect stings due to their playful behavior and curiosity. Preventive measures specifically tailored for children include: - Educate Your Child : Teach them to recognize stinging insects and to avoid them. - Keep Snacks Covered : When outside, ensure that all sweets and snacks are in closed containers. - Supervision During Outdoor Play : Monitor outdoor activities and ensure play areas are free of nests and hives. - Consider Medical Identification : Children with known severe allergies may benefit from wearing a medical alert bracelet. Implementing these preventive strategies can help keep children safe and reduce the risk of distress caused by insect stings. Conclusion  Insect sting allergies can be serious and potentially life-threatening, but there are effective treatments available to manage symptoms and reduce risks. The combination of immediate first aid, emergency epinephrine use, and long-term venom immunotherapy provides a comprehensive approach to treatment. By working closely with an allergist, individuals can customize a treatment plan that fits their specific needs. It's crucial to stay informed about preventative measures and treatment options to ensure safety and peace of mind during outdoor activities.
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